BiP Binding Keeps ATF6 at Bay

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Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response.

Endoplasmic reticulum (ER) stress-induced activation of ATF6, an ER membrane-bound transcription factor, requires a dissociation step from its inhibitory regulator, BiP. It has been generally postulated that dissociation of the BiP-ATF6 complex is a result of the competitive binding of misfolded proteins generated during ER stress. Here we present evidence against this model and for an active r...

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ژورنال

عنوان ژورنال: Developmental Cell

سال: 2002

ISSN: 1534-5807

DOI: 10.1016/s1534-5807(02)00210-1